Ocular histoplasmosis syndrome in the United Kingdom.

Reid, Scherer, Herbut, and Irving (I 942) noted nodules surrounded by haemorrhage in both maculae of a patient dying of systemic histoplasmosis. A relationship between a form of uveitis with specific morphological features and evidence of exposure to Histoplasma capsulatum was also suggested by Day (I 949), Krause and Hopkins (I 95 I), and Schlaegel (I 958). Woods and Wahlen (i959) described a specific ocular complex characterized by multiple small, discrete, focal, nonpigmented or sparsely pigmented lesions or scars in the mid or peripheral fundus (Fig. I) and a "disciform" lesion in the foveal or perifoveal area with or without surrounding haemorrhage (Fig. 2). They determined that patients with these features were frequently sensitive to histoplasmin skin antigen and postulated that systemic infection with Histoplasma capsulatum was responsible for this specific ocular condition. Later investigators have added to the above complex peripapillary chorio-retinal scarring